HMGA2-induced epithelial–mesenchymal transition is reversed by let-7d in intrauterine adhesions
نویسندگان
چکیده
منابع مشابه
Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer.
Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide. Let-7 family has been shown to function as a tumor suppressor through regulating multiple oncogenic signaling. Recent study reported that combined underexpression of miR-205 and let-7d showed negative correlation with the survival prognosis of head and neck cancer patients. However, the let-7d-involved mechanism in regulating ...
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Intrauterine adhesion (IUA) is a common cause for secondary infertility. However, traditional treatment nowadays can only restore the shape of the uterine cavity but not the inadequate endometrium. In this study, we investigated the therapeutic potentials of induced pluripotent stem cells (iPSCs) to treat IUA in a mouse model and further explore the role of heme-oxygenase-1 (HO-1) gene in exert...
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The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations in these publications. There were 28 studies inclu...
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To elucidate the molecular mechanisms underlying the progression of head and neck squamous cell carcinoma (HNSCC), we investigated the function of let-7c as a tumor suppressor. Let-7c expression was significantly down-regulated in HNSCC tumor tissues and cell lines. In vitro and in vivo studies revealed that let-7c negatively regulated HNSCC proliferation, migration and epithelial-mesenchymal t...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2020
ISSN: 1460-2407
DOI: 10.1093/molehr/gaaa074